Negative Regulator of IFN Regulatory Small Ubiquitin - Related Modifier

Negative Regulator of IFN Regulatory Factor 7 Ubiquitin - Related Modifier E 3 Ligase and Tripartite Motif - Containing Protein 28 Is a Small

http://www.jimmunol.org/content/187/9/4754 doi:10.4049/jimmunol.1101704 September 2011; 2011;187;4754-4763; Prepublished online 21 J Immunol Rauscher III, Keiko Ozato and Fanxiu Zhu Qiyi Tang, Tsung-Hsien Chang, Hongzhuang Peng, Frank J. Qiming Liang, Hongying Deng, Xiaojuan Li, Xianfang Wu, Negative Regulator of IFN Regulatory Factor 7 Ubiquitin-Related Modifier E3 Ligase and Tripartite Motif-...

Negative Regulator of IFN Regulatory Small Ubiquitin - Related Modifier E 3 Ligase Tripartite Motif - Containing Protein 28

Negative Regulator of IFN Regulatory Small Ubiquitin - Related Modifier E 3 Ligase Tripartite Motif - Containing Protein 28 Is a

Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.

IFN regulatory factor 7 (IRF7) is a potent transcription factor of type I IFNs and IFN-stimulated genes and is known as the master regulator of type I IFN-dependent immune responses. Because excessive responses could harm the host, IRF7 itself is delicately regulated at the transcriptional, translational, and posttranslational levels. Modification of IRF7 by small ubiquitin-related modifiers (S...

Smurf2 negatively modulates RIG-I-dependent antiviral response by targeting VISA/MAVS for ubiquitination and degradation.

VISA (also known as MAVS, Cardif, IPS-1) is the essential adaptor protein for virus-induced activation of IFN regulatory factors 3 and 7 and production of type I IFNs. Understanding the regulatory mechanisms for VISA will provide detailed insights into the positive or negative regulation of innate immune responses. In this study, we identified Smad ubiquitin regulatory factor (Smurf) 2, one of ...